Protective effect of a combination of the peptide mimicking the spatial structure of the B erythropoietin chain and infliximab on the epithelium of the nephron tubules in renal ischemia-reperfusion injury

Purpose: Due to the severe clinical course and high socio-economic significance of acute kidney injury, issue methods for diagnosing treating this pathology is on agenda scientific community around world. One most specific biomarkers injury KIM-1. KIM-1 an apical transmembrane protein proximal renal tubule. Elevated levels in a model ischemia-reperfusion kidneys correlate with inflammation fibrosis histological studies. The aim work was study protective effects combination peptide mimicking -helix B erythropoietin (pHBSP) infliximab epithelium nephron tubules kidneys. Methods: experiment conducted 80 white laboratory male Wistar rats weighing 280320 g. Animals were injected infliximab. Under anesthesia, atraumatic vascular clamps applied left pedicle 40 minutes, nephrectomy right. Within 12 hours after reperfusion, urine samples collected Results: According results experiment, it found that use more effectively protected from damage during than administration or mono mode. Conclusion: clearly substantiate prospects combined protect tubule injury.